Comparison of lenograstim and filgrastim on haematological effects after autologous peripheral blood stem cell transplantation with high-dose chemotherapy
- Authors
- Kim, IH; Park, SK; Suh, OK; Oh, JM
- Issue Date
- Dec-2002
- Publisher
- LIBRAPHARM
- Keywords
- filgrastim; G-CSF; lenograstim; neutropenia; PBSCT
- Citation
- CURRENT MEDICAL RESEARCH AND OPINION, v.19, no.8, pp 753 - 759
- Pages
- 7
- Journal Title
- CURRENT MEDICAL RESEARCH AND OPINION
- Volume
- 19
- Number
- 8
- Start Page
- 753
- End Page
- 759
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16365
- DOI
- 10.1185/030079903125002531
- ISSN
- 0300-7995
1473-4877
- Abstract
- Objective: To compare the efficacy of lenograstim and filgrastim on haematological recovery following an autologous peripheral blood stem cell transplantation (PBSCT) with high-dose chemotherapy. Methods: A retrospective case-controlled study. Results: Absolute neutrophil count (ANC) recovery above 0.5 x 10(9)/1 and white blood cell (WBC) recovery above 4 x 10(9)/1 for 3 consecutive days was achieved earlier with filgrastim than with lenograstim ((13.2 +/- 8.0 vs 19.0 +/- 10.0 days, p = 0.004), (16.9 +/- 9.7 vs 29.9 +/- 16.6 days, p = 0.001), respectively). The platelet recovery above 20 x 10(9)/1 was also achieved earlier with filgrastim than with lenograstim (19.5 +/- 11.6 vs 27.2 +/- 13.8 days, p = 0.006). Furthermore, filgrastim-treated patients received fewer days of granulocyte colony simulating factor (G-CSF) administration (12.5 +/- 7.0 vs 18.6 +/- 8.5 days, p = 0.001) and spent less time in hospital (23.7 +/- 10.9 vs 32.0 +/- 17.6 days, p = 0.009). Duration of antibiotic administration was also significantly shorter in the filgrastim group (13.6 +/- 7.6 vs 29.1 +/- 19.8 days, p = 0.001). Conclusion: In patients undergoing PBSCT following high-dose chemotherapy, filgrastim significantly reduced the duration of neutropenia, thrombocytopenia and days of G-CSF administration, and led to earlier hospital discharge compared with lenograstim.
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