Involvement of p38 mitogen-activated protein kinase in the induction of interleukin-12 p40 production in mouse macrophages by berberine, a benzodioxoloquinolizine alkaloid
- Authors
- Kang, BY; Chung, SW; Cho, D; Kim, TS
- Issue Date
- May-2002
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- berberine; interleukin-12; p38 MAPK; macrophage; lipopolysaccharide; T helper
- Citation
- BIOCHEMICAL PHARMACOLOGY, v.63, no.10, pp 1901 - 1910
- Pages
- 10
- Journal Title
- BIOCHEMICAL PHARMACOLOGY
- Volume
- 63
- Number
- 10
- Start Page
- 1901
- End Page
- 1910
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16414
- DOI
- 10.1016/S0006-2952(02)00982-6
- ISSN
- 0006-2952
1873-2968
- Abstract
- Interleukin (IL)-12 plays a pivotal role in the development of T helper type 1 (Th1)-immune response, which may have therapeutic effects on diseases associated with pathologic Th2 responses such as allergic disorders and asthma. In this study, we investigated the effects of berberine, a benzodioxoloquinolizine alkaloid with anti-microbial and anti-tumor activities, on the production of IL-12 p40, an inducible subunit of IL-12, in mouse macrophages. Berberine-induced IL-12 p40 production and activation of p38 mitogen-activated protein kinase (MAPK) in dose-dependent manners, which were significantly inhibited by p38 MAPK inhibitors and yohimbine, indicating that p38 MAPK and alpha(2)-adrenergic receptor were involved in the induction of IL-12 p40 production in mouse macrophages by berberine. Furthermore, berberine significantly enhanced IL-12 p40 production in mouse macrophages when combined with lipopolysaccharide, a well-known inducer of IL-12 production. These findings may explain some of the known biological effects of berberine and suggests berberine as an immunotherapeutic compound for induction of IL-12, which is potentially applicable for tumors, infectious disease, and airway inflammation. (C) 2002 Elsevier Science Inc. All rights reserved.
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