Protective Effect of Soybean Saponins and Major Antioxidants Against Aflatoxin B1-Induced Mutagenicity and DNA-Adduct Formation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hye-Seung Jun | - |
dc.contributor.author | Sung-Eun Kim | - |
dc.contributor.author | Mi-Kyung Sung | - |
dc.date.available | 2021-02-22T16:32:20Z | - |
dc.date.issued | 2002-12 | - |
dc.identifier.issn | 1096-620X | - |
dc.identifier.issn | 1557-7600 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16448 | - |
dc.description.abstract | Saponins from various plant sources have ben suggested as possible anticarcinogens. Majordietary sources of saponins include legumes such as soybeans. This study was performed todetermine the effect of soybean saponins on aflatoxin B 1(AFB1) induced mutagenicity andAFB1-DNA aduct formation using Salmonella typhimurium and human liver hepatoma(HepG2) cells, respectively. Major antioxidants including L-ascorbic acid, a-tocopherol, all-trans-retinol, and butylated hydroxytoluene (BHT), previously reported to possess antimuta-genic activity, were used as test materials to evaluate the relative effectiveness of saponins.Results indicated antimutagenicity was in the order of BHT . saponins . a-tocopherol .L-ascorbic acid. Soybean saponins exerted a significant effect, inhibiting the mutagenicity ofAFB1 by 52%, 64%, and 81% at concentrations of 60, 90, and 1,20 mg per plate, respectively.The amount of tritiated AFB 1 metabolites DNA aducts formed in HepG2 cells was signif-icantly reduced when cells were preincubated with 10 or 30 mg/ml of test materials. Soybeansaponins inhibited AFB 1-DNA aduct formation by 50.1% at a concentration of 30 mg/ml,whereas L-ascorbic acid and BHT reduced aduct formation by 38.4% and 32.6%, respectively,at the same concentrations. These results indicate that soybean saponins possess not only asignificant antimutagenic activity but a strong inhibitory action against carcinogen-inducedDNA damages. Soybean saponins possibly block the initiation stage of carcinogenesis, andfurther studies are required to elucidate the mechanisms of action.235 | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 한국식품영양과학회 | - |
dc.title | Protective Effect of Soybean Saponins and Major Antioxidants Against Aflatoxin B1-Induced Mutagenicity and DNA-Adduct Formation | - |
dc.title.alternative | Protective Effect of Soybean Saponins and Major Antioxidants Against Aflatoxin B1-Induced Mutagenicity and DNA-Adduct Formation | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.1089/109662002763003393 | - |
dc.identifier.scopusid | 2-s2.0-0036934192 | - |
dc.identifier.bibliographicCitation | Journal of Medicinal Food, v.5, no.4, pp 235 - 240 | - |
dc.citation.title | Journal of Medicinal Food | - |
dc.citation.volume | 5 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 235 | - |
dc.citation.endPage | 240 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.url | https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART000993354 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Sookmyung Women's University. Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul, 04310, Korea02-710-9127
Copyright©Sookmyung Women's University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.