Effect of coadministration of enriched Korean red ginseng (Panax ginseng) and American ginseng (Panax quinquefolius L) on cardiometabolic outcomes in type-2 diabetes: A randomized controlled trial
DC Field | Value | Language |
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dc.contributor.author | Jovanovski, Elena | - |
dc.contributor.author | Smircic-Duvnjak, Lea | - |
dc.contributor.author | Komishon, Allison | - |
dc.contributor.author | Au-Yeung, Fei (Rodney) | - |
dc.contributor.author | Sievenpiper, John L. | - |
dc.contributor.author | Zurbau, Andreea | - |
dc.contributor.author | Jenkins, Alexandra L. | - |
dc.contributor.author | Sung, Mi-Kyung | - |
dc.contributor.author | Josse, Robert | - |
dc.contributor.author | Li, Dandan | - |
dc.contributor.author | Vuksan, Vladimir | - |
dc.date.available | 2021-03-15T02:40:34Z | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 1226-8453 | - |
dc.identifier.issn | 2093-4947 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/17533 | - |
dc.description.abstract | Background Diabetes mellitus and hypertension often occur together, amplifying cardiovascular disease (CVD) risk and emphasizing the need for a multitargeted treatment approach. American ginseng (AG) and Korean red ginseng (KRG) species could improve glycemic control via complementary mechanisms. Additionally, a KRG-inherent component, ginsenoside Rg3, may moderate blood pressure (BP). Our objective was to investigate the therapeutic potential of coadministration of Rg3-enriched Korean red Ginseng (Rg3-KRG) and AG, added to standard of care therapy, in the management of hypertension and cardiometabolic risk factors in type-2 diabetes. Methods Within a randomized controlled, parallel design of 80 participants with type-2 diabetes (HbA1c: 6.5–8%) and hypertension (systolic BP: 140–160 mmHg or treated), supplementation with either 2.25 g/day of combined Rg3-KRG + AG or wheat-bran control was assessed over a 12-wk intervention period. The primary endpoint was ambulatory 24-h systolic BP. Additional endpoints included further hemodynamic assessment, glycemic control, plasma lipids and safety monitoring. Results Combined ginseng intervention generated a mean ± SE decrease in primary endpoint of 24-h systolic BP (−3.98 ± 2.0 mmHg, p = 0.04). Additionally, there was a greater reduction in HbA1c (−0.35 ± 0.1% [–3.8 ± 1.1 mmol/mol], p = 0.02), and change in blood lipids: total cholesterol (−0.50 ± 0.2 mmol/l, p = 0.01), non-HDL-C (−0.54 ± 0.2 mmol/l, p = 0.01), triglycerides (−0.40 ± 0.2 mmol/l, p = 0.02) and LDL-C (−0.35 ± 0.2 mmol/l, p = 0.06) at 12 wks, relative to control. No adverse safety outcomes were observed. Conclusion Coadministration of Rg3-KRG + AG is an effective addon for improving BP along with attaining favorable cardiometabolic outcomes in individuals with type 2 diabetes. Ginseng derivatives may offer clinical utility when included in the polypharmacy and lifestyle treatment of diabetes. Clinical trial registration Clinicaltrials.gov identifier, NCT01578837; Keywords GinsengHypertensionRandomized controlled trialType-2 diabetes | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 고려인삼학회 | - |
dc.title | Effect of coadministration of enriched Korean red ginseng (Panax ginseng) and American ginseng (Panax quinquefolius L) on cardiometabolic outcomes in type-2 diabetes: A randomized controlled trial | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.1016/j.jgr.2019.11.005 | - |
dc.identifier.scopusid | 2-s2.0-85077561258 | - |
dc.identifier.wosid | 000688366900002 | - |
dc.identifier.bibliographicCitation | Journal of Ginseng Research, v.45, no.5, pp 546 - 554 | - |
dc.citation.title | Journal of Ginseng Research | - |
dc.citation.volume | 45 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 546 | - |
dc.citation.endPage | 554 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002785092 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.subject.keywordPlus | BLOOD-PRESSURE | - |
dc.subject.keywordPlus | GLYCEMIA | - |
dc.subject.keywordPlus | INDIVIDUALS | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | THERAPIES | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | GLUCOSE | - |
dc.subject.keywordPlus | TIME | - |
dc.subject.keywordAuthor | Ginseng | - |
dc.subject.keywordAuthor | Hypertension | - |
dc.subject.keywordAuthor | Randomized controlled trial | - |
dc.subject.keywordAuthor | Type-2 diabetes | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S122684531930106X?via%3Dihub | - |
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