Detailed Information

Cited 0 time in webofscience Cited 3 time in scopus
Metadata Downloads

Red meat intake, CYP2E1 and PPAR gamma polymorphisms, and colorectal cancer risk

Authors
Kim, Na-HuiSeol, Ju EunKim, JeongseonLee, Bong-HwaHwang, Dae-YongJeong, JinyoungLee, Hun-JaeAhn, Yoon-OkKim, Dong-HyunLee, Jung Eun
Issue Date
Jul-2019
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Keywords
colorectal cancer; PPAR gamma polymorphism; red meat intake
Citation
EUROPEAN JOURNAL OF CANCER PREVENTION, v.28, no.4, pp.304 - 310
Journal Title
EUROPEAN JOURNAL OF CANCER PREVENTION
Volume
28
Number
4
Start Page
304
End Page
310
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/2961
DOI
10.1097/CEJ.0000000000000462
ISSN
0959-8278
Abstract
The association between red meat intake and colorectal cancer (CRC) may be modulated by genetic polymorphisms of cytochrome P450 2E1 (CYP2E1), a key enzyme in the metabolism of nitrosamines, and peroxisome proliferator-activated receptor gamma (PPAR gamma), a transcription factor involved in adipogenesis and lipid and glucose metabolism. We conducted a case-control study of 971 patients with CRC and 658 controls who were admitted to two university hospitals between 1995 and 2004 in Seoul, Korea. Participants were asked about red meat intake by using a validated food frequency questionnaire. Polymorphisms of CYP2E1 (rs3813867) and PPAR gamma (rs1801282 or rs3856806) were identified using the TaqMan assay. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using multivariable logistic regression models. We found that the association between red meat and CRC varied by CYP2E1 polymorphisms; ORs (95% CIs) for at least five or more vs. less than one time/week of red meat intake were 2.77 (1.23-6.25) among individuals with C alleles of CYP2E1 and 0.89 (0.51-1.54) among individuals with the GG allele (P-interaction=0.05). Compared with those individuals with the CC allele, increasing risk of CRC with increasing red meat intake was more pronounced among individuals with T alleles of PPAR gamma C161T (rs3856806), but the association was not significant. Our data provide evidence that East Asians with the variant type of CYP2E1 may have high susceptibility to development of CRC risk.
Files in This Item
Go to Link
Appears in
Collections
생활과학대학 > 식품영양학과 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE