Chemopreventive Action of Anthocyanin-rich Black Soybean Fraction in APCMin/+ Intestinal Polyposis Model
DC Field | Value | Language |
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dc.contributor.author | 박미영 | - |
dc.contributor.author | 김정미 | - |
dc.contributor.author | 김정상 | - |
dc.contributor.author | 정명근 | - |
dc.contributor.author | 성미경 | - |
dc.date.available | 2021-02-22T10:49:40Z | - |
dc.date.issued | 2015-09 | - |
dc.identifier.issn | 2288-3649 | - |
dc.identifier.issn | 2288-3657 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/5314 | - |
dc.description.abstract | Background: Anthocyanins have been shown to inhibit cancer cell growth by suppressing oxidative stress and inflammatory responses. The purpose of this study was to investigate the effects of an anthocyanin-rich extract (AE) from black soybean coat on intestinal carcinogenesis. Methods: ApcMin/+ mice were fed a diet of 0.2% or 0.5% AE for 7 weeks. We analyzed the number of intestinal tumors, oxidative stress and inflammatory markers associated with β-catenin and cytosolic phospholipase A2 (cPLA2) signals. The number of intestinal tumors, and cellular expression of β-catenin were determined. Results: The number of intestinal tumors was significantly lower in mice fed a 0.5% AE diet compared to those of the other groups. Cytosolic β-catenin expression was significantly decreased in the AE supplemented groups compared to that of the control animals. In addition, mucosa expression of cyclooxygenase-2 and cPLA2 were also significantly decreased in the 0.5% AE group, by 32% and 62%, respectively, compared to the control group. Conclusions: These results suggest that dietary AE reduced the development of intestinal tumors, possibly through the ability to suppress oxidative stresses, decreasing inflammatory responses mediated by β-catenin associated signals. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한암예방학회 | - |
dc.title | Chemopreventive Action of Anthocyanin-rich Black Soybean Fraction in APCMin/+ Intestinal Polyposis Model | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.15430/JCP.2015.20.3.193 | - |
dc.identifier.bibliographicCitation | 대한암예방학회지, v.20, no.3, pp 193 - 201 | - |
dc.citation.title | 대한암예방학회지 | - |
dc.citation.volume | 20 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 193 | - |
dc.citation.endPage | 201 | - |
dc.identifier.kciid | ART002035603 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Anthocyanins | - |
dc.subject.keywordAuthor | APCMin/+ | - |
dc.subject.keywordAuthor | Black soybean | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Intestinal tumors | - |
dc.identifier.url | https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002035603 | - |
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