Carnosic Acid Inhibits Lipid Accumulation in 3T3-L1 Adipocytes Through Attenuation of Fatty Acid Desaturation
DC Field | Value | Language |
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dc.contributor.author | Mi-Young Park | - |
dc.contributor.author | Mi Kyung Sung | - |
dc.date.available | 2021-02-22T10:51:41Z | - |
dc.date.issued | 2015-03 | - |
dc.identifier.issn | 2288-3649 | - |
dc.identifier.issn | 2288-3657 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/5549 | - |
dc.description.abstract | Background:Excess body fat accumulation contributes to the development of metabolic disorders that can cause adverse health effects. Carnosic acid (CA), a major bioactive component of rosemary (Rosemarinus officinalis), has been suggested to possess anti-adipogenicproperties. The present study was conducted to elucidate the mechanism underlying the anti-adipogenic effects of CA. Methods:3T3-L1 pre-adipocytes were treated with CA (0.1, 1, and 10 μM) from day 0 to day 8 of differentiation. On day 8, biochemicalmarkers of lipid accumulation and the degree of fatty acid desaturation were measured. Results:Oil Red O staining results, triglyceride (TG) accumulation, and glycerol 3-phosphate dehydrogenase activity suggested that CAsignificantly inhibited lipid accumulation in 3T3-L1 adipocytes. CA significantly decreased mRNA expression of peroxisome proliferator-activated receptor-γ, sterol regulatory element-binding protein 1, and CCAAT/enhancer binding protein-αin a dose-dependent manner. Moreover, it decreased the ratio of both C16:1/C16:0 and C18:1/C18:0, with reduced expression of stearoyl CoA desaturase 1 mRNAand protein. Conclusions:These results suggest that CA efficiently suppressed adipogenesis in 3T3-L1 adipocytes and its action, at least in part, isassociated with the downregulation of adipogenesis-related genes and the fatty acid composition of TG accumulated in adipocytes. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한암예방학회 | - |
dc.title | Carnosic Acid Inhibits Lipid Accumulation in 3T3-L1 Adipocytes Through Attenuation of Fatty Acid Desaturation | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.15430/JCP.2015.20.1.41 | - |
dc.identifier.bibliographicCitation | 대한암예방학회지, v.20, no.1, pp 41 - 49 | - |
dc.citation.title | 대한암예방학회지 | - |
dc.citation.volume | 20 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 41 | - |
dc.citation.endPage | 49 | - |
dc.identifier.kciid | ART001976066 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | 3T3-L1 adipocytes | - |
dc.subject.keywordAuthor | Carnosic acid | - |
dc.subject.keywordAuthor | Differentiation | - |
dc.subject.keywordAuthor | Fatty acid | - |
dc.identifier.url | https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001976066 | - |
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