Inhibitory effect of a sesquiterpene from artemisia iwayomogi on expression of inducible nitric oxide synthase by suppression of I-κBα degradation in LPS-stimulated RAW 264.7 cellsopen access
- Authors
- Kim, Na Yeon; Koh, Hye Jin; Li, Hua; Lee, Hwa Jin; Ryu, Jae-Ha
- Issue Date
- Jun-2017
- Publisher
- Korean Society of Pharmacognosy
- Keywords
- Armefolin; Artemisia iwayomogi; Inducible nitric oxide synthase; Nitric oxide; Sesquiterpene
- Citation
- Natural Product Sciences, v.23, no.2, pp 92 - 96
- Pages
- 5
- Journal Title
- Natural Product Sciences
- Volume
- 23
- Number
- 2
- Start Page
- 92
- End Page
- 96
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/8306
- DOI
- 10.20307/nps.2017.23.2.92
- ISSN
- 1226-3907
- Abstract
- A sesquiterpene was purified from Artemisia iwayomogi methanolic extract during the course of searching anti-inflammatory principle from medicinal plants. A sesquiterpene identified as armefolin inhibited the production of nitric oxide (NO) and attenuated inducible nitric oxide synthase (iNOS) protein level in lipopoly-saccharide (LPS)-activated RAW 264.7 cells. Armefolin also down-regulated mRNA expressions of iNOS and pro-inflammatory cytokines, interleukin-1β and interleukin-6 in LPS-activated macrophages. Moreover, armefolin suppressed the degradation of inhibitory-κBα (I-κBα) in LPS-activated macrophages. These data suggest that armefolin from A. iwayomogi can suppress the LPS-induced production of NO and the expression of iNOS gene through inhibiting the degradation of I-κBα. Taken together, armefolin from A. iwayomogi might be a candidate as promising anti-inflammatory agent. © 2017, Korean Society of Pharmacognosy. All rights reserved.
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