Hawthorn Fruit Extract Elevates Expression of Nrf2/HO-1 and Improves Lipid Profiles in Ovariectomized Rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoo, Jeong-Hyun | - |
dc.contributor.author | Liu, Yanan | - |
dc.contributor.author | Kim, Hyun-Sook | - |
dc.date.available | 2021-02-22T11:27:23Z | - |
dc.date.issued | 2016-05 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/9821 | - |
dc.description.abstract | The purpose of this study was to investigate the effects of hawthorn (Crataegus pinnatifida Bunge) extract on the lipid profiles and antioxidant properties in ovariectomized (OVX) rats. After ovariectomy, the rats were randomly divided into four groups: the non-OVX control (Sham), the OVX-control (OVX), the OVX + 100 mg/kg b.w. of hawthorn extract (OL), and the OVX + 200 mg/kg b.w. of hawthorn extract (OH). The final body weights of the OVX group were significantly increased, but the increment was significantly decreased in hawthorn groups (p < 0.05). The serum total and low-density lipoprotein (LDL) cholesterol levels were significantly elevated in the OVX group, whereas the hawthorn groups showed a significant decrease in these levels (p < 0.05). The hepatic triglyceride (TG) and malondialdehyde (MDA) levels were significantly reduced in the hawthorn groups compared with the OVX group (p < 0.05). The mRNA expression of nuclear factor erythroid 2-related factor (Nrf2), heme oxygenase-1 (HO-1), and glutathione peroxidase (GPx) were significantly decreased in the OVX group, whereas the hawthorn groups exhibited a significant increase in expression (p < 0.05). The protein expressions of Nrf2, HO-1, and GPx were lower in the OVX group than the Sham group (p < 0.05). The oral administration of hawthorn extract reversed the suppression of protein levels. These results suggest that hawthorn extract could have protective effects in OVX rats by improving lipid profiles, decreasing oxidative stress, and improving the antioxidant defense system. | - |
dc.format.extent | 16 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | Hawthorn Fruit Extract Elevates Expression of Nrf2/HO-1 and Improves Lipid Profiles in Ovariectomized Rats | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/nu8050283 | - |
dc.identifier.scopusid | 2-s2.0-84969256174 | - |
dc.identifier.wosid | 000378780900044 | - |
dc.identifier.bibliographicCitation | NUTRIENTS, v.8, no.5, pp 283 - 298 | - |
dc.citation.title | NUTRIENTS | - |
dc.citation.volume | 8 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 283 | - |
dc.citation.endPage | 298 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | HEME OXYGENASE-1 | - |
dc.subject.keywordPlus | CRATAEGUS-PINNATIFIDA | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | SERUM-LIPIDS | - |
dc.subject.keywordPlus | DRIED FRUIT | - |
dc.subject.keywordPlus | CELL-CYCLE | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | LIVER | - |
dc.subject.keywordPlus | NRF2 | - |
dc.subject.keywordPlus | CHOLESTEROL | - |
dc.subject.keywordAuthor | hawthorn extract | - |
dc.subject.keywordAuthor | antioxidant | - |
dc.subject.keywordAuthor | oxidative stress | - |
dc.subject.keywordAuthor | nuclear factor erythroid 2 related factor | - |
dc.subject.keywordAuthor | heme oxygenase-1 | - |
dc.subject.keywordAuthor | glutathione peroxidase | - |
dc.subject.keywordAuthor | ovariectomized | - |
dc.identifier.url | https://www.mdpi.com/2072-6643/8/5/283 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Sookmyung Women's University. Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul, 04310, Korea02-710-9127
Copyright©Sookmyung Women's University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.