Quercetin and kaempferol suppress immunoglobulin E-mediated allergic inflammation in RBL-2H3 and Caco-2 cells
- Authors
- Lee, Eun-Ju; Ji, Geun-Eok; Sung, Mi-Kyung
- Issue Date
- Oct-2010
- Publisher
- SPRINGER BASEL AG
- Keywords
- Allergy; Quercetin; Kaempferol; Intestinal barrier; IgE
- Citation
- INFLAMMATION RESEARCH, v.59, no.10, pp 847 - 854
- Pages
- 8
- Journal Title
- INFLAMMATION RESEARCH
- Volume
- 59
- Number
- 10
- Start Page
- 847
- End Page
- 854
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13120
- DOI
- 10.1007/s00011-010-0196-2
- ISSN
- 1023-3830
1420-908X
- Abstract
- We investigated the inhibitory effects of quercetin and kaempferol treatment on the suppression of immunoglobulin E (IgE)-mediated allergic responses in relation to intestinal epithelium barrier function in RBL-2H3 and Caco-2 cells. RBL-2H3 cells as a model of intestinal mucosa mast cells were treated with flavonols followed by IgE-anti-dinitrophenyl sensitization. The extent of degranulation and the release of pro-inflammatory cytokines were measured. Caco-2 cells were stimulated with interleukin (IL)-4 or IgE-allergen with or without flavonol pretreatment and changes in the expression of CD23 mRNA and mitogen-activated protein kinase (MAPK), and chemokine release were determined. Flavonols inhibited the secretion of allergic mediators in RBL-2H3 cells and suppressed the CD23 mRNA expression and p38 MAPK activation in IL-4 stimulated Caco-2 cells. Flavonols also suppressed IgE-OVA induced extra signal-regulated protein kinase (ERK) activation and chemokine release. Quercetin and kaempferol effectively suppressed the development of IgE-mediated allergic inflammation of intestinal cell models.
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