Sources of Polycyclic Aromatic Hydrocarbon Exposure in Non-Occupationally Exposed Koreans
- Authors
- Yang M.; Kang D.; Choi Y.; Lee S.-M.; Kim S.; Lee E.; Cheong H.-K.; Chang S.-S.; Jang J.-Y.
- Issue Date
- Jan-2003
- Publisher
- John Wiley & Sons Inc.
- Keywords
- 1-hydroxypyrene; Biomarker; Exposure route; Genetic polymorphism; Polycyclic aromatic hydrocarbons
- Citation
- Environmental and Molecular Mutagenesis, v.42, no.4, pp 250 - 257
- Pages
- 8
- Journal Title
- Environmental and Molecular Mutagenesis
- Volume
- 42
- Number
- 4
- Start Page
- 250
- End Page
- 257
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/149206
- DOI
- 10.1002/em.10196
- ISSN
- 0893-6692
1098-2280
- Abstract
- Urinary 1-hydroxypyrene (1-OHP), an exposure biomarker for polycyclic aromatic hydrocarbons (PAHs), was used to identify potential sources of PAH exposure for 660 Koreans who were not occupationally exposed to PAHs (65% male; 35% female; mean age, 36.5 ± 11.1 years). In this study, 74% of subjects had detectable levels of urinary 1-OHP, with a concentration range of 0.001-3.796 μg/L (median, 0.079 μg/L). A backward elimination was conducted: five variables were selected with a significance level for removal of P ≤ 0.1. The results of this study showed that residence in areas with relatively poor environmental conditions (Seoul and Suwon) was strongly associated with high concentrations of urinary 1-OHP (P = 0.007), while consumption of fried chicken and length of time spent outdoors had marginal positive associations with urinary 1-OHP levels (P = 0.06 and P = 0.09, respectively). Compared with the above three factors, tobacco smoking and urinary cotinine levels were poorly associated with urinary 1-OHP (P = 0.16 and 0.23, respectively). Pear consumption had an inverse association with urinary 1-OHP levels (P < 0.01). Individual variations in urinary 1-OHP concentrations were evaluated by considering the subjects' age, sex, and genetic polymorphisms in enzymes involved in the metabolism of PAHs. Among the indivi
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