미역의 섭취가 화학적으로 유도된 쥐의 대장암화 표지자인 Aberrant Crypt 형성 및 상피세포 분열에 미치는 영향에 관한 연구Effect of Fiber - Rich Sea Mustard Feeding on AOM - Induced Colon Aberrant Crypt Formation and Colonic Cell Proliferation in Sprague Dawley Rats
- Other Titles
- Effect of Fiber - Rich Sea Mustard Feeding on AOM - Induced Colon Aberrant Crypt Formation and Colonic Cell Proliferation in Sprague Dawley Rats
- Authors
- 이은주; 성미경
- Issue Date
- Jun-2001
- Publisher
- 한국식품영양과학회
- Citation
- 한국식품영양과학회지, v.30, no.3, pp 535 - 539
- Pages
- 5
- Journal Title
- 한국식품영양과학회지
- Volume
- 30
- Number
- 3
- Start Page
- 535
- End Page
- 539
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/149432
- ISSN
- 1226-3311
2288-5978
- Abstract
- 본 연구는 미역을 섬유소원으로 첨가한 식이가 대장암 발생에 미치는 효과를 생체 내에서 판정하기 위해 실시되었다. 발암원을 주사한 쥐의 식이에 15% 수준으로 미역분말을 첨가하여 암화단계별로 공급한 결과 대장에서 생성되는 aberrant crypt foci(ACF) 수 및 aberrant crypt(AC) 수가 미역식이에 의해 현저하게 감소하는 효과를 관찰할 수 있었다. 특히 AC의 수는 일부기간 먹인 군보다 전기간 먹인 군에게서 유의하게 적었다. 또 미역식이는 발암원 처리에 의한 crypt length, labeling index(%) 및 proliferation zone(%)의 증가를 억제하였다. 이를 기초로 효과성분 분리 및 구체적 기전규명이 이루어진다면 미역을 포함하는 해조류의 암 예방 효과 및 치료 효능과 관련한 새로운 가치가 부각되리라 본다.
The modulating effect of feeding sea mustard (Undarina pinnatifida), a fiber-rich seaweed, during initiation and post-initiation phases of colon carcinogenesis was investigated in Sprague Dawley rats. Four groups of animals were exposed to the two weekly injections of a chemical carcinogen, azoxymethane (AOM). Animals were placed on diet containing 15% sea mustard during initiation, post-initiation or initiation+post-initiation phase of carcinogenesis for 10 weeks, and colonic aberrant crypt formation and cell proliferation were compared to those of rats fed semi-synthetic control diet. Results showed that sea mustard feeding significantly reduced the numbers of both aberrant crypts and aberrant crypt foci. Also, labeling indices and proliferation zones were significantly reduced in the colon of the rats fed sea mustard diets. These results indicate that the diet containing sea mustard may decrease the risk of colon cancer development, and a part of such effect may be mediated through both the blocking of initiation and the suppression of cell proliferation in the colonic crypts, although precise mechanisms should be further examined.
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