Effects of glutathione S-transferase (GST) M1 and GSTT1 genotypes on urothelial cancer risk
- Authors
- Katoh, T.; Inatomi, H.; Kim, H.; Yang, M.; Matsumoto, T.; Kawamoto, T.
- Issue Date
- Oct-1998
- Publisher
- Elsevier BV
- Citation
- Cancer Letters, v.132, no.1-2, pp 147 - 152
- Pages
- 6
- Journal Title
- Cancer Letters
- Volume
- 132
- Number
- 1-2
- Start Page
- 147
- End Page
- 152
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/150228
- DOI
- 10.1016/S0304-3835(98)00183-9
- ISSN
- 0304-3835
1872-7980
- Abstract
- The M1 member of the mu class of the glutathione S-transferase (GSTM1) gene is present in about 50% of individuals. GSTT1, a member of the theta class, which has been recently shown to be polymorphic, is expressed in 35-90% of individuals. In this study, 145 Japanese patients with urothelial transitional cell carcinoma and 145 healthy controls, frequency-matched for age and gender, were compared for frequencies of GSTM1 and GSTT1 genotypes. The urothelial cancer risk increased due to the GSTM1 null genotype (odds ratio (OR) 1.71, 95% confidence interval (CI) 1.05-2.79). On the other hand, the OR tended to decrease due to the GSTT1 null genotype, although not significantly. Among individuals of the GSTM1 null genotype, those of the GSTT1-positive genotype had a two-fold risk (OR 2.62, 95% CI 1.36-5.05) compared with the GSTT1 null genotype (OR 1.25, 95% CI 0.62-2.51). A significant interaction between the GSTM1 genotype and smoking status was found; the GSTM1 null genotype was associated with an increased risk of urothelial cancer among smokers (OR 1.98, 95%CI 1.10-3.57). Copyright (C) 1998 Elsevier Science Ireland Ltd.
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