청국장이 난소적출 마우스의 면역 기능에 미치는 영향Effects of fermented soybean paste Chungkukjang on the immunoreactivity in ovariectomized mice
- Other Titles
- Effects of fermented soybean paste Chungkukjang on the immunoreactivity in ovariectomized mice
- Authors
- 박현진; 윤이나; 김현숙
- Issue Date
- Dec-2013
- Publisher
- Korean Society of Food Science and Nutrition
- Keywords
- Chungkukjang; Cytokine production; Ovariectomized mice; Splenocytes proliferation; T lymphocyte subsets
- Citation
- Journal of the Korean Society of Food Science and Nutrition, v.42, no.12, pp 1930 - 1939
- Pages
- 10
- Journal Title
- Journal of the Korean Society of Food Science and Nutrition
- Volume
- 42
- Number
- 12
- Start Page
- 1930
- End Page
- 1939
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/6231
- DOI
- 10.3746/jkfn.2013.42.12.1930
- ISSN
- 1226-3311
2288-5978
- Abstract
- It has been reported that Chungkukjang, one of Korean traditional fermented soybean products, may improve hypertension, diabetes, and hyperlipidemia. In this study, we sought to investigate the immunoenhancing effects of Chungkukjang in ovariectomized mice. For the first period, female SLC ddy mice were either sham-operated (Sham; n=27) or ovariectomized (OVX; n=27). As a basal diet, ovariectomized mice were fed low-calcium diet for faster induction of osteoporosis for six weeks, and those in the Sham group were fed AIN-76 diet. For the second period, half of the OVX group (n=9) and the Sham group (n=9) were fed a Chungkukjang-based diet (CKJ); whereas the other half (OVX; n=9/ Sham; n=9) were fed a casein-based diet (CSI) for 8 weeks. After a second period, we collected the blood via heart puncture and measured the splenocytes proliferation, T lymphocyte subsets by flowcytometry, and levels of serum cytokines (IL-2, IL-4, IL-6, IL-10, IFN-γ and TNF-α) by ELISA assay. The OVX+CKJ group showed higher splenocytes proliferation, higher ratio of CD4/CD8, and lower levels of IL-6 and TNF-α cytokines compared to the OVX+CSI group. The Sham+CKJ group showed cytokine productions, such as higher levels of IL-10 and IFN-γ, and lower levels of IL-6 and TNF-α compared to the Sham+CSI group. The result of this study suggests that Chungkukjang may lower the proinflammatory cytokine levels in both the OVX and Sham groups. In addition, Chungkukjang could make a balance of T cell subset proliferations and enhance the splenocyte proliferations in the OVX group.
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