방사선 조사된 흰쥐에서 고단백식이와 레스베라트롤 첨가가 영양상태 및 면역기능 증진에 미치는 효과Effect of High Protein Diet and Resveratrol Supplementation on the Nutritional Status and Immunoreactivity in the Irradiation-induced Inflammatory Rats
- Other Titles
- Effect of High Protein Diet and Resveratrol Supplementation on the Nutritional Status and Immunoreactivity in the Irradiation-induced Inflammatory Rats
- Authors
- 김경옥; 전미선; 강승희; 김현숙
- Issue Date
- Oct-2009
- Publisher
- 한국영양학회
- Keywords
- radiation treatment; high protein diet; resveratrol; immunoreactivity; nutrition status
- Citation
- Journal of Nutrition and Health, v.42, no.7, pp 605 - 614
- Pages
- 10
- Journal Title
- Journal of Nutrition and Health
- Volume
- 42
- Number
- 7
- Start Page
- 605
- End Page
- 614
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/7499
- ISSN
- 2288-3886
2288-3959
- Abstract
- Most cancer patients are treated with surgery, chemotherapy or radiation as anticancer therapies. Especially in the
case of radiation, these treatments produce adverse effects such as vomiting, weight loss, anorexia, normal cell damage
and malabsorption. The major goal of this study was to determine the effect of irradiation on the nutritional and immune
status in irradiated rats. A secondary goal was to determine the effectiveness of high protein diet (HP) and resveratrol
(Res) in minimizing the adverse effects of radiation. Rats were divided into four groups: normal diet (NP), HP, NP +
Res and HP + Res groups. Each group was further divided into subgroups that received radiation (RT group) and one
that did not (non-RT group). Each diet was supplied from 12th day prior to irradiation treatment with irradiation dose of
17.5 Gy. The diets were continued until 10th day after radiation treatment and animals were sacrificed. The radiation
treatment showed decreased body weight, serum protein and HDL levels and increased TG and LDL levels in nutritional
status. HP, NP + Res and HP + Res groups reduced the level of serum LDL and TG in irradiated rats. NP + Res
and HP + Res groups increased reduced albumin level of serum in RT group. In case of immune status, the radiation
treat-ment showed decreased WBC, lymphocytes and increased neutrophil and eosinophil levels. The levels of serum
IL-2 and IL-6 were significantly increased by radiation, however the cytokine levels decreased in all dietary treatment
groups. These results showed that high protein diet and resveratrol supplementation seem to minimize the adverse
effects of radiation on lipid nutritional status and inflammation response in the rat model. (Korean J Nutr 2009; 42(7):
605 ~ 614)
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