Plasma, tissue and urinary levels of aloin in rats after the administration of pure aloin
- Authors
- 박미영; 권훈정; 성미경
- Issue Date
- Mar-2008
- Publisher
- 한국영양학회
- Keywords
- Aloin; rats; plasma; tissue; urine
- Citation
- Nutrition Research and Practice, v.2, no.1, pp 17 - 21
- Pages
- 5
- Journal Title
- Nutrition Research and Practice
- Volume
- 2
- Number
- 1
- Start Page
- 17
- End Page
- 21
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/7984
- ISSN
- 1976-1457
2005-6168
- Abstract
- Aloin is a physiologically active anthraquinone present in aloe. There are two isomers of aloin, aloin A and aloin B, occurring as a mixture
of diastereomers. The objective of this study was to determine the bioavailability and tissue distribution of aloin. Rats were gavaged with 11.8g/kg
aloin, and the levels of aloin and its conjugates were measured in plasma, tissues, and urine. Plasma aloin level showed a peak at 1hr after the
administration and the concentration was 59.07±10.5 ng/ml. The 24 h cumulated urinary aloin was 0.03% of the initial dose. These results suggest
that aloin is absorbed and reaches a peak plasma level within 1-1.5 h after the administration and a significant portion is possibly metabolized
or is excreted in feces. These results can apply to the determination of the adequate intake level of aloe and aloe products to achieve the desired
biological effect, and to interprete in vitro study results.
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