Elm bark extract improves immunomodulation and ameliorates oxidative stress in irradiated mice
- Authors
- Lee Y.-S.; Kim H.; Kim H.-S.; Lee H.-J.
- Issue Date
- Mar-2017
- Publisher
- Elsevier B.V.
- Keywords
- elm bark; immune system; intestinal damage; mice; radiation
- Citation
- Journal of Ethnic Foods, v.4, no.1, pp 15 - 20
- Pages
- 6
- Journal Title
- Journal of Ethnic Foods
- Volume
- 4
- Number
- 1
- Start Page
- 15
- End Page
- 20
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/8636
- DOI
- 10.1016/j.jef.2017.01.001
- ISSN
- 2352-6181
2352-619X
- Abstract
- Background Radiation therapy can result in side effects such as cellular and tissue inflammation and organ damage. Previously, elm bark (EB) extract has been reported to exert antioxidant and anti-inflammatory effects. In this study, we investigated whether EB administration could improve immunocompetence and ameliorate radiation-induced intestinal damage in irradiated mice. Methods After exposure to radiation of 15 Gy, mice were orally administered with EB extract (0 mg/kg, 50 mg/kg, and 500 mg/kg body weight) every other day for 2 weeks, and there was a 2-week washout period. The proliferation of splenocytes and cytokine production of macrophage were measured as indices of immune activity, and histological grade and antioxidant levels in radiation-induced intestinal injury were measured. Results Radiation exposure reduced the T-cell proliferation in splenocytes and the levels of interleukin-1β and interleukin-6 from macrophage at Week 2. The supplement of EB extract at low concentration (50 mg/kg body weight; EB-50) tended to enhance T-and B-cell proliferation in irradiated mice. The histological grades of the small intestine were induced by radiation exposure, whereas histological grade of the EB-50 group was lower than that of the irradiated control at Week 4. The EB-50 treatment reduced the level of glutathione at Day 5 and Week 2 and reduced myeloperoxidase activity at Week 4, suggesting that EB-50 may counteract the intestinal inflammation caused by radiation exposure. Conclusion Our results indicate that EB extract (50 mg/kg body weight) protects against radiation damage, at least in part, by improving immunomodulation and ameliorating oxidative stress in irradiated mice. © 2017 Korea Food Research Institute
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