Six-week open-label trial of topiramate to treat disruptive behaviors in children and adolescents with or without mental retardation
- Authors
- Shin W.C.; Song D.H.; Ha E.H.; Shin Y.J.
- Issue Date
- Sep-2006
- Publisher
- 대한신경정신의학회
- Keywords
- Disruptive behavior; Mental retardation; Topiramate; Youth
- Citation
- Psychiatry Investigation, v.3, no.2, pp 73 - 80
- Pages
- 8
- Journal Title
- Psychiatry Investigation
- Volume
- 3
- Number
- 2
- Start Page
- 73
- End Page
- 80
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/8778
- ISSN
- 1738-3684
1976-3026
- Abstract
- Objective: Anticonvulsants are known to be effective to manage affective instability and aggressive behavior by reducing neuronal excitability. This study examined the efficacy and safety of topiramate, a novel anticonvulsant, on disruptive behavioral problems in children and adolescents, with or without mental retardation (MR), and the differences of short-term efficacy and safety according to the IQ levels. Methods and Materials: Fifty-four children and adolescents with disruptive behavioral problems were enrolled in a 6-week, open-label study. All subjects were divided into 3 groups (subjects without MR, Non-MR; subjects with mild MR, Mild MR; and subjects with moderate to severe MR, Mod-Severe MR) based on their intellectual ability, and treated with topiramate. Outcome measures included the Aberrant Behavior Checklist Hyperactivity (ABC-H) and Irritability (ABC-I) subscales and the Clinical Global Impression Severity (CGI-S) scale. Results: Significant reduction of CGI-S, ABC-H, and ABC-I scores were noted in all three groups in the following order: Non-MR, Mild MR, and Mod-Severe MR. Parethesia, anorexia, somnolence, nocturnal enuresis, and urinary frequency were relatively common adverse event. However, no serious adverse events were reported. Conclusions: Topiramate was effective and well tolerated for managing disruptive behavioral problems and emotional instability in children and adolescents.
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