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Evaluation of Aloin and Aloe-Emodin as Anti-Inflammatory Agents in Aloe by Using Murine Macrophages

Authors
Park, Mi-YoungKwon, Hoon-JeongSung, Mi-Kyung
Issue Date
Apr-2009
Publisher
TAYLOR & FRANCIS LTD
Keywords
aloin; aloe-emodin; polyphenol; anti-inflammatory effect
Citation
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.73, no.4, pp.828 - 832
Journal Title
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume
73
Number
4
Start Page
828
End Page
832
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13792
DOI
10.1271/bbb.80714
ISSN
0916-8451
Abstract
The aloe ingredients responsible for physiological effects and the concentrations required to exert their biological activities are not fully understood. This study compares the anti-inflammatory effects of aloin and aloe-emodin with other polyphenols. Our results demonstrated that aloe-emodin dose-dependently inhibited inducible nitric oxide synthase (iNOS) mRNA expression and nitric oxide (NO) production at 5-40 mu M. In addition, the levels of cyclooxygenase-2 (COX-2) mRNA and prostaglandin E-2 (PGE(2)) production were suppressed by 40 mu M aloe-emodin. Aloin also suppressed the production of NO at 5-40 mu M, although it did not suppress PGE(2) production. The present results indicate that aloin and aloe-emodin possibly suppress the inflammatory responses by blocking iNOS and COX-2 mRNA expression. The anti-inflammatory effect of aleo-emodin was comparable to that of kaempferol and quercetin, indicating aloe-emodin as a possible key constituent responsible for the anti-inflammatory activity of aloe.
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생활과학대학 (식품영양학과)
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