Anti-proliferative and anti-carcinogenic enzyme-inducing activities of delphinidin in hepatoma cells
- Authors
- Jang, Chan Ho; Lee, In Ae; Lim, Hyun Ae; Kim, Ju Ryoung; Ha, Young Ran; Yu, Hoon; Sung, Mi-Kyung; Kim, Jong-Sang
- Issue Date
- Aug-2007
- Publisher
- KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
- Keywords
- delphinidin; antioxidant; cancer prevention; quinone reductase
- Citation
- FOOD SCIENCE AND BIOTECHNOLOGY, v.16, no.4, pp 641 - 645
- Pages
- 5
- Journal Title
- FOOD SCIENCE AND BIOTECHNOLOGY
- Volume
- 16
- Number
- 4
- Start Page
- 641
- End Page
- 645
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14657
- ISSN
- 1226-7708
2092-6456
- Abstract
- Delphinidin, an aglycone form of anthocyanins, was demonstrated to have anti-carcinogenic potential. The compound at 50 mu g/mL caused a significant increase of quinone reductase activity, an anti-carcinogenic marker enzyme, in mouse hepatoma cell lines (Hepalc1c7 and BPRcl). Delphinidin enhanced the expression of other detoxifying or antioxidant enzymes including glutathione S-transferase, gamma-glutamylcysteine synthetase, heme oxygenase 1, and glutathione reductase. It suppressed the proliferation of murine hepatoma cells in a dose-dependent manner, with approximately IC50 of 70 mu g/mL. These results suggest that delphinidin might be useful for cancer prevention.
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